We discuss joint work with Mark Peletier, Giuseppe Savare, Michiel Renger, and Matthias Liero concerning the derivation of generalized gradient structures for reaction-diffusion systems. The energy is the relative energy while the dual dissipation functional is the sum of a quadratic diffusion term (of Wasserstein type) and and an exponential term for the reactions. We show that this form arises from three different cases: (1) via the large-deviation principle for the Markov processes with Brownian motion as well as jumps; (2) for reaction arising as evolutionary Gamma limit from a Fokker-Planck equation with a high potential barrier (3) for transmission conditions arising as evolutionary Gamma limit for an entropic gradient flow with a thin layer with very low mobility. It is interesting that in the cases (2) and (3) we obtain a generalized gradient flow (i.e. the dissipation potential is non-quadratic) as an evolutionary Gamma limit form classical gradient flows (i.e. quadratic dissipation potential).