The classical Entropy Power Inequality (EPI) bounds the Shannon entropy of the sum of random variables, and is at the basis of information theory and probability. Its proof is based on the heat semigroup and on the so-called Stam inequality on the Fisher information of a convolution. The setup of the EPI can represent the addition of Gaussian noise to a given signal, so this inequality has been crucial for the determination of the capacity of various Gaussian communication channels. However, the electromagnetic field used in radio communications is ultimately a quantum-mechanical entity. We prove a quantum generalization the EPI (qEPI), that permits to extend to the quantum setting all the results on channel capacities obtained with its classical counterpart. Our proof is based on the quantum version of the heat semigroup and on a quantum generalization of the Stam inequality. Our qEPI supports the validity of the so-called Entropy Photon Number Inequality, the last of a series of entropic inequalities associated with Bosonic systems still left unsolved.